Scientific Investigations Report 2007–5106
U.S. GEOLOGICAL SURVEY
Scientific Investigations Report 2007–5106
Table 2. Relationships between the descriptive 1996, 1999, and 2005 USEPA Weight-of-Evidence cancer classifications and the three equations used to calculate HBSLs.
[USEPA, U.S. Environmental Protection Agency; HBSL, Health-Based Screening Level; USEPA OW, Office of Water]
| USEPA Weight-of-Evidence Descriptors | OW equation used to calculate HBSL | ||
|---|---|---|---|
| 1996 (U.S. Environmental Protection Agency, 1996) | 1999 (U.S. Environmental Protection Agency, 1999) | 2005 (U.S. Environmental Protection Agency, 2005) | |
| Known/likely | Carcinogenic to humans | Carcinogenic to humans | Cancer Risk Concentration (eq. 1) |
| — | Likely to be carcinogenic to humans | Likely to be carcinogenic to humans | Cancer Risk Concentration (eq. 1) |
| — | Suggestive evidence of carcinogenicity but not sufficient to assess human carcinogenic potential | Suggestive evidence of carcinogenic potential | Lifetime Health Advisory (Lifetime HA) for Group C carcinogens (eq. 2) |
| Cannot be determined | Data are inadequate for an assessment of human carcinogenic potential | Inadequate information to assess carcinogenic potential | Lifetime HA (eq. 3) |
| Not likely | Not likely to be carcinogenic to humans | Not likely to be carcinogenic to humans | Lifetime HA (eq. 3) |
| Multiple narrative descriptors such as: “Likely to be carcinogenic to humans under high-dose conditions but not likely to be carcinogenic to humans under low-dose conditions‟ | Lifetime HA (eq. 3)1 | ||
| No Weight-of-Evidence descriptor, but reference dose is available | Lifetime HA (eq. 3) | ||
1Equation 3 for Lifetime HA values is used with these types of multiple narrative Weight-of-Evidence descriptors because concentrations detected in the environment typically are low.
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