S. M. Plakas G. R. Stehly 1992 The pharmacokinetics, tissue distribution, and metabolism of 1-naphthol were examined in the channel catfish (Ictalurus punctatus ). After oral dosing, peak plasma concentrations of 1-naphthol occurred at 1 hr; parent compound made up less than 15% of the total radioactivity, and the bioavailability was 32%. Plasma protein binding was 92% and was independent of concentration. 1-Naphthol and metabolites were rapidly eliminated from the tissues after oral dosing. application/pdf en U.S. Food and Drug Administration Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus) article