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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>J. L. Coffine</dc:contributor>
  <dc:contributor>G. F. Combs Jr.</dc:contributor>
  <dc:creator>H. A. Poston</dc:creator>
  <dc:date>1982</dc:date>
  <dc:description>&lt;p&gt;A 16-wk feeding study was conducted to evaluate the chronic toxicity of graded levels (0, 1.0, 2.5.5, 10 and 15 mg/kg of chemically pure dietary T-2 toxin (4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ&lt;sup&gt;9&lt;/sup&gt;-tricothecen-3-ol) in 1-g rainbow trout,&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;Salmo gairdneri&lt;/i&gt;, held in 9°C single-passage well water. Levels of T-2 toxin &amp;gt; 2.5 mg/kg depressed growth, efficiency of feed use, hematocrit, blood hemoglobin concentration and feed acceptance, and caused a transitory edema in a dose-dependent manner. Growth of trout fed a semipurified diet containing the toxin was described by the function:&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;Y&lt;/i&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;= 0.265 + 142.075 e&lt;sup&gt;(0.029&lt;i&gt;X&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt;&lt;/sup&gt;− 1.554x&lt;sub&gt;2&lt;sup&gt;3.7&lt;/sup&gt;&lt;/sub&gt;), where&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;Y&lt;/i&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;= gain as percentage starting weight per wk;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;X&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;is time in wk and 0 ⩽&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;X&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt;⩽16; and&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;X&lt;/i&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;is T-2 content of diet in mg/kgand 0⩽&lt;i&gt;X&lt;/i&gt;&lt;sub&gt;2&lt;/sub&gt;⩽15.&lt;/p&gt;&lt;p&gt;Exposure of fish to T-2 toxin did not affect activity of intestinal lumen chymoirypsin or trypsin, nitrogen digestibility or metabolizabte energy. Feeding of 15 mg/kg T-2 toxin to adult trout caused hemorrhaging in the intestines and regurgitation of subsequently intubated feed regardless of T-2 loxin content.&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1016/0166-445X(82)90007-8</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Biological effects of dietary T-2 toxin on rainbow trout, Salmo gairdneri</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>