K.M. Kelley G. Young R. S. Nishioka H. A. Bern S. D. McCormick 1992 <p><span>The effect of insulin-like growth factor I on growth rate of coho salmon (</span><i>Oncorhynchus kisutch</i><span>) was examined. Juvenile coho salmon received implants of osmotic minipumps containing recombinant bovine insulin-like growth factor I (rbIGF-I) or saline for a period of 3 to 4 weeks. High doses of rbIGF-I (&gt;0.13 μg · g</span>⁻¹<span>&nbsp;· d</span>⁻¹<span>) resulted in hypoglycemia and death. In 2-year-old coho salmon, 0.09 μg · g</span>⁻¹<span>&nbsp;· d</span>⁻¹<span>&nbsp;rbIGF-I administered for 25 days doubled linear growth rate and increased growth rate in weight by 40%. In rapidly growing, 1-year-old coho salmon, growth rate was not altered by rbIGF-I at 0.01 or 0.05 μg · g</span>⁻¹<span>&nbsp;· d</span>⁻¹<span>&nbsp;for 31 days. In ration-limited fish exhibiting slow growth in the control group, rbIGF-I (0.02 to 0.12 μg · g</span>⁻¹<span>&nbsp;· d</span>⁻¹<span>) increased linear growth rate by up to threefold and growth rate in weight by up to fourfold. The results indicate that exogenous treatment with mammalian IGF-I can stimulate coho salmon growth under some conditions, and that endogenous IGF-I may be an important factor in regulating growth of teleosts.</span></p> application/pdf 10.1016/0016-6480(92)90064-Q en Elsevier Stimulation of coho salmon growth by insulin-like growth factor I article