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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>S. D. McCormick</dc:contributor>
  <dc:creator>J. M. Shrimpton</dc:creator>
  <dc:date>1998</dc:date>
  <dc:description>&lt;p&gt;&lt;span&gt;The potential effects of growth hormone (GH), prolactin (Prl), and triiodothyronine (T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;) on gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity and corticosteroid receptor (CR) concentration (&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;) and dissociation constant (&lt;/span&gt;&lt;i&gt;K&lt;/i&gt;&lt;sub&gt;d&lt;/sub&gt;&lt;span&gt;) were examined in juvenile Atlantic salmon (&lt;/span&gt;&lt;i&gt;Salmo salar&lt;/i&gt;&lt;span&gt;). Compared to controls, fish injected with GH (ovine, 5.0 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;) had significantly greater gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity after 7 and 14 days. Gill CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;and&lt;/span&gt;&lt;i&gt;K&lt;/i&gt;&lt;sub&gt;d&lt;/sub&gt;&lt;span&gt;were significantly elevated on day 7, but not day 14. T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;also significantly increased CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;. The effect of GH on CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;was also additive with T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;(5.0 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;) treatment. There was a synergistic effect on CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;when purified coho salmon GH (csGH, 0.1 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;) was injected in combination with T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;(1.6 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;). Prl (ovine, 5.0 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;; purified coho salmon, 0.1 μg g&lt;/span&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;span&gt;) did not significantly alter gill CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;. Although Prl limited the increase in CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;by GH, the effect was not signicant. T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;and Prl did not have an effect on&lt;/span&gt;&lt;i&gt;K&lt;/i&gt;&lt;sub&gt;d&lt;/sub&gt;&lt;span&gt;. GH significantly increased gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity, T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;administration did not have a significant effect, and Prl-treated fish had significantly lower gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity. The results indicate that T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;acts additively with GH, while Prl has no effect in regulating CR&lt;/span&gt;&lt;i&gt;B&lt;/i&gt;&lt;sub&gt;max&lt;/sub&gt;&lt;span&gt;. An increase in cytosolic CR by GH and T&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;span&gt;, but not Prl, may regulate gill responsiveness to cortisol and be an important mechanism in the endocrine control of physiological changes during the parr–smolt transformation.&lt;/span&gt;&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1006/gcen.1998.7172</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Regulation of gill cytosolic corticosteroid receptors in juvenile Atlantic salmon: Interaction effects of growth hormone with prolactand triiodothyronine</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>