<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>S. D. McCormick</dc:contributor>
  <dc:creator>J. M. Mancera</dc:creator>
  <dc:date>1998</dc:date>
  <dc:description>&lt;p&gt;&lt;span&gt;The ability of ovine growth hormone (oGH), recombinant bovine insulin-like growth factor I (rbIGF-I), recombinant human insulin-like growth factor II (rhIGF-II), and bovine insulin to increase hypoosmoregulatory capacity in the euryhaline teleost&lt;/span&gt;&lt;i&gt;Fundulus heteroclitus&lt;/i&gt;&lt;span&gt;was examined. Fish acclimated to brackish water (BW, 10 ppt salinity, 320 mOsm/kg H&lt;/span&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;span&gt;O) were injected with a single dose of hormone and transferred to seawater (SW, 35 ppt salinity, 1120 mOsm/kg H&lt;/span&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;span&gt;O) 2 days later. Fish were sampled 24 h after transfer and plasma osmolality, plasma glucose, and gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity were examined. Transfer from BW to SW increased plasma osmolality and gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity. Transfer from BW to BW had no effect on these parameters. rbIGF-I (0.05, 0.1, and 0.2 μg/g) improved the ability to maintain plasma osmolality and to increase gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;, K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity in a dose-dependent manner. oGH (0.5, 1, and 2 μg/g) also increased hypoosmoregulatory ability but only the higher doses (2 μg/g) significantly increased gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity. oGH (1 μg/g) and rbIGF-I (0.1 μg/g) had a significantly greater effect on plasma osmolality and gill Na&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;,K&lt;/span&gt;&lt;sup&gt;+&lt;/sup&gt;&lt;span&gt;-ATPase activity than either hormone alone. rhIGF-II (0.05, 0.1, and 0.2 μg/g) and bovine insulin (0.01 and 0.05 μg/g) were without effect. The results suggest a role of GH and insulin-like growth factor I (IGF-I) in seawater acclimation of&lt;/span&gt;&lt;i&gt;F. heteroclitus.&lt;/i&gt;&lt;span&gt;Based on these findings and previous studies, it is concluded that the capacity of the GH/IGF-I axis to increase hypoosmoregulatory ability may be a common feature of euryhalinity in teleosts.&lt;/span&gt;&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1006/gcen.1998.7086</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Evidence for growth hormone/insulin-like growth factor I axis regulation of seawater acclimation in the euryhaline teleost Fundulus heteroclitus</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>