Dora R. Passino-Reader James P. Hickey 1991 For the linear solvation energy relationship (LSER), values are listed for each of the variables (V_i/100, π*, &beta_m, α_m) for fundamental organic structures and functional groups. We give the guidelines to estimate LSER variable values quickly for a vast array of possible organic compounds such as those found in the environment. The difficulty in generating these variables has greatly discouraged the application of this quantitative structure-activity relationship (QSAR) method. This paper present the first compilation of molecular functional group values together with a utilitarian set of the LSER variable estimation rules. The availability of these variable values and rules should facilitate widespread application of LSER for hazard evaluation of environmental contaminants. application/pdf 10.1021/es00022a012 en ACS Publications Linear solvation energy relationships: "rule of thumb" for estimation of variable values article