W. L. Hayton A.E. Staubus S.W. Fisher M.J. Lydy 1994 <p><span>A two compartment pharmacokinetic model was developed which describes the uptake and elimination of 5,5′,6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) in the midge,&nbsp;</span><i>Chironomus riparius. C. riparius</i><span>&nbsp;were exposed to nominal TCB (2 μg L</span>⁻¹<span>) and PCP (9 μg L</span>⁻¹<span>) concentrations during a 16 h static uptake phase. Depuration was determined over approximately 45 h using a flowthrough system without feeding. The uptake clearance (P) was 330±61 ml g</span>⁻¹<span>&nbsp;midge h</span>⁻¹<span>&nbsp;for TCB and 55±4 ml g</span>⁻¹<span>&nbsp;midge h</span>⁻¹<span>&nbsp;for PCP, while measured bioconcentration factors (BCF) were 35,900 and 458 for TCB and PCP, respectively. Overall, the clearance-volume-based pharmacokinetic model predicted BCF values that were consistent with published values as well as with BCF values obtained from the octanol-water partition coefficient (K</span>_OW<span>).</span></p> application/pdf 10.1007/BF00224812 en Springer Bioconcentration of 5,5′,6 -trichlorobiphenyl and pentachlorophenol in the midge, Chironomus riparius, as measured by a pharmacokinetic model article