S. Corbeil G. R. Jones W. D. Shewmaker N. Lorenzen Eric Anderson Gael Kurath S. E. LaPatra 2001 <div id="abstracts" class="Abstracts u-font-serif"><div id="aep-abstract-id11" class="abstract author"><div id="aep-abstract-sec-id12"><p>A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (<i>Oncorhynchus mykiss</i>) held at 15°C. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 μg.</p></div></div></div> application/pdf 10.1016/S0264-410X(01)00113-X en Elsevier Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination article