Rebecca S. Lazarus Gary H. Heinz Natalie K. Karouna-Reiner Sandra L. Schultz Robert C. Hale Barnett A. Rattner 2013 Concentrations of polybrominated diphenyl ethers (PBDEs) in Forster’s tern (<i>Sterna forsteri</i>) eggs from San Francisco Bay have been reported to range up to 63 μg g⁻¹ lipid weight. This value exceeds the lowest-observed-adverse-effect level (1.8 μg g⁻¹ egg wet weight; ∼32 μg⁻¹ lipid weight) reported in an embryotoxicity study with American kestrels (<i>Falco sparverius</i>). As a surrogate for Forster’s terns, common tern (<i>Sterna hirundo</i>) eggs were treated by air cell injection with corn oil vehicle (control) or a commercial penta-BDE formulation (DE-71) at nominal concentrations of 0.2, 2, and 20 μg g⁻¹ egg. As a positive control, kestrel eggs received vehicle or 20 μg DE-71 g⁻¹ egg. In terns, there were no effects of DE-71 on embryonic survival, and pipping or hatching success; however, treated eggs hatched later (0.44 d) than controls. Organ weights, organ-to-body weight ratios, and bone lengths did not differ, and histopathological observations were unremarkable. Several measures of hepatic oxidative stress in hatchling terns were not affected by DE-71, although there was some evidence of oxidative DNA damage (8-hydroxy-deoxyguanosine; 8-OH-dG). Although DE-71 did not impair pipping and hatching of kestrels, it did result in a delay in hatch, shorter humerus length, and reduced total thyroid weight. Concentrations of oxidized glutathione, reduced glutathione, thiobarbituric acid reactive substances, and 8-OH-dG in liver were greater in DE-71-treated kestrels compared to controls. Our findings suggest common tern embryos, and perhaps other tern species, are less sensitive to PBDEs than kestrel embryos. application/pdf 10.1016/j.chemosphere.2013.05.030 en Elsevier Comparative embryotoxicity of a pentabrominated diphenyl ether mixture to common terns (<i>Sterna hirundo</i>) and American kestrels (<i>Falco sparverius</i>) article