Rodman G. Getchell Emily R. Cornwell Gregory A. Wooster H. George Ketola Paul R. Bowser Kate E. Breyer 2015 <p>Juvenile rainbow trout, <i>Oncorhynchus mykiss</i>, were fed diets containing 0, 0.5, 1.0, and 2.0% of a garlic extract, challenged with a modified 50% lethal dose of <i>Aeromonas salmonicida</i> and monitored for 28 d. There were significant increases in survival of trout fed 0.5 and 1.0% garlic extract as compared to the control and 2.0% garlic extract groups. A target animal safety study was performed at varying increments using the target dose of 0.5% garlic extract at 0&times; (0% garlic extract), 1&times; (0.5% garlic extract), 3&times; (1.5% garlic extract), and 5&times; (2.5% garlic extract) for 3&times; (6&thinsp;wk) the duration of the original study. There was a significant increase in the level of circulating lymphocytes and a significant decrease in the level of circulating monocytes. The latter correlated to an increased level of pigment-containing macrophage centers within the renal tissue as garlic extract dosing increased, denoting a potential deleterious inflammatory effect as macrophage infiltration became severe at the highest dose. These studies suggest that feeding low-dose (0.5% or 1.0%) garlic extract improves survivability in rainbow trout when challenged with<i> A. salmonicida</i> and appears safe; however, higher levels do not appear to be effective and may cause deleterious effects on health.</p> application/pdf 10.1111/jwas.12195 en World Aquaculture Society Efficacy of an extract from garlic, Allium sativum, against infection with the furunculosis bacterium, Aeromonas salmonicida, in rainbow trout, Oncorhynchus mykiss article