Gary Wedemeyer
1967
<p><span>Whole cells or cell-free extracts of </span><i>Aerobacter aerogenes</i><span> catalyze the degradation of 1,1,1-trichloro-2,2-bis(</span><i>p</i><span>-chlorophenyl)ethane (DDT) in vitro to at least seven metabolites: 1,1-dichloro-2,2-bis(</span><i>p</i><span>-chlorophenyl)ethylene (DDE); 1,1-dichloro-2,2-bis(</span><i>p</i><span>-chlorophenyl)ethane (DDD); 1-chloro-2,2-bis(</span><i>p</i><span>-chlorophenyl)ethylene (DDMU); 1-chloro-2,2-bis(</span><i>p</i><span>-chlorophenyl)ethane (DDMS); unsym-bis(</span><i>p</i><span>-chlorophenyl)ethylene (DDNU); 2,2-bis(</span><i>p</i><span>-chlorophenyl)acetate (DDA); and 4,4′-dichlorobenzophenone (DBP). The use of metabolic inhibitors together with </span><i>p</i><span>H and temperature studies indicated that discrete enzymes are involved. By use of the technique of sequential analysis, the metabolic pathway was shown to be: DDT → DDD →DDMU →DDMS → DDNU → DDA → DBP, or DDT → DDE. Dechlorination was marginally enhanced by light-activated flavin mononucleotide.</span></p>
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10.1128/am.15.3.569-574.1967
en
American Society for Microbiology
Dechlorination of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane by Aerobacter aerogenes: I. Metabolic products
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