Michael D. Samuel
Trent Bollinger
Margo Pybus
David W. Coltman
Tomomi Matsumoto
2013
<p><span>Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white-tailed deer (</span><i>Odocoileus virginianus</i><span>) and mule deer (</span><i>Odocoileus hemionus</i><span>) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross-species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 cM). Markers near the prion protein and the neurofibromin 1 (</span><i>NF1</i><span>) genes were suggestively associated with CWD status in white-tailed deer (</span><i>P </i><span>=</span><i> </i><span>0.006) and mule deer (</span><i>P </i><span>=</span><i> </i><span>0.02), respectively. This is the first time an association between the </span><i>NF1</i><span> region and CWD has been reported.</span></p>
application/pdf
10.1111/eva.12003
en
Blackwell Publishing Ltd
Association mapping of genetic risk factors for chronic wasting disease in wild deer
article