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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>Silas K. Phipps-Costin</dc:contributor>
  <dc:contributor>Chelsea K. Fujimoto</dc:contributor>
  <dc:contributor>Ingibjorg E. Einarsdottir</dc:contributor>
  <dc:contributor>Amy M. Regish</dc:contributor>
  <dc:contributor>Björn Thrandur Björnsson</dc:contributor>
  <dc:contributor>Stephen D. McCormick</dc:contributor>
  <dc:creator>Jason P. Breves</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description>&lt;p&gt;&lt;span&gt;The growth hormone (Gh)/insulin-like growth-factor (Igf) system plays a central role in the regulation of growth in fishes. However, the roles of Igf binding proteins (Igfbps) in coordinating responses to food availability are unresolved, especially in anadromous fishes preparing for seaward migration. We assayed plasma Gh, Igf1, thyroid hormones and cortisol along with&amp;nbsp;&lt;/span&gt;&lt;i&gt;igfbp&amp;nbsp;&lt;/i&gt;&lt;span&gt;mRNA levels in fasted and fed Atlantic salmon (&amp;nbsp;&lt;/span&gt;&lt;i&gt;Salmo salar&amp;nbsp;&lt;/i&gt;&lt;span&gt;). Fish were fasted for 3 or 10 days near the peak of smoltification (late April to early May). Fasting reduced plasma glucose by 3 days and condition factor by 10 days. Plasma Gh, cortisol, and thyroxine (T&amp;nbsp;&lt;/span&gt;&lt;sub&gt;4&amp;nbsp;&lt;/sub&gt;&lt;span&gt;) were not altered in response to fasting, whereas Igf1 and 3,5,3&amp;prime;-triiodo-&amp;nbsp;&lt;/span&gt;&lt;span class="small-cap"&gt;l&amp;nbsp;&lt;/span&gt;&lt;span&gt;-thyronine (T&amp;nbsp;&lt;/span&gt;&lt;sub&gt;3&amp;nbsp;&lt;/sub&gt;&lt;span&gt;) were slightly higher and lower than controls, respectively. Hepatic&amp;nbsp;&lt;/span&gt;&lt;i&gt;igfbp1b1&amp;nbsp;&lt;/i&gt;&lt;span&gt;, -&amp;nbsp;&lt;/span&gt;&lt;i&gt;1b2&amp;nbsp;&lt;/i&gt;&lt;span&gt;, -&amp;nbsp;&lt;/span&gt;&lt;i&gt;2a&amp;nbsp;&lt;/i&gt;&lt;span&gt;, -&amp;nbsp;&lt;/span&gt;&lt;i&gt;2b1&amp;nbsp;&lt;/i&gt;&lt;span&gt;and -&amp;nbsp;&lt;/span&gt;&lt;i&gt;2b2&amp;nbsp;&lt;/i&gt;&lt;span&gt;mRNA levels were not responsive to fasting, but there were marked increases in&amp;nbsp;&lt;/span&gt;&lt;i&gt;igfbp1a1&amp;nbsp;&lt;/i&gt;&lt;span&gt;following 3 and 10 days of fasting. Fasting did not alter hepatic&amp;nbsp;&lt;/span&gt;&lt;i&gt;igf1&lt;/i&gt;&lt;span&gt;or&amp;nbsp;&lt;/span&gt;&lt;i&gt;igf2&amp;nbsp;&lt;/i&gt;&lt;span&gt;; however, muscle&amp;nbsp;&lt;/span&gt;&lt;i&gt;igf1&amp;nbsp;&lt;/i&gt;&lt;span&gt;was diminished by 10 days of fasting. There were no signs that fasting compromised branchial ionoregulatory functions, as indicated by unchanged Na&amp;nbsp;&lt;/span&gt;&lt;sup&gt;+&amp;nbsp;&lt;/sup&gt;&lt;span&gt;/K&amp;nbsp;&lt;/span&gt;&lt;sup&gt;+&amp;nbsp;&lt;/sup&gt;&lt;span&gt;-ATPase activity and ion pump/transporter mRNA levels. We conclude that dynamic hepatic&amp;nbsp;&lt;/span&gt;&lt;i&gt;igfbp1a1&amp;nbsp;&lt;/i&gt;&lt;span&gt;and muscle&amp;nbsp;&lt;/span&gt;&lt;i&gt;igf1&amp;nbsp;&lt;/i&gt;&lt;span&gt;expression participate in the modulation of Gh/Igf signaling in smolts undergoing catabolism.&lt;/span&gt;&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1016/j.ygcen.2016.05.015</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Hepatic insulin-like growth-factor binding protein (igfbp) responses tofood restriction in Atlantic salmon smolts</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>