<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>Karen Slaght</dc:contributor>
  <dc:contributor>Michael A. Boogaard</dc:contributor>
  <dc:creator>Jean V. Adams</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description>&lt;p&gt;&lt;span&gt;The authors developed a package, LW1949, for use with the statistical software R to automatically carry out the manual steps of Litchfield and Wilcoxon's method of evaluating dose&amp;ndash;effect experiments. The LW1949 package consistently finds the best fitting dose&amp;ndash;effect relation by minimizing the chi-squared statistic of the observed and expected number of affected individuals and substantially speeds up the line-fitting process and other calculations that Litchfield and Wilcoxon originally carried out by hand.&amp;nbsp;&lt;/span&gt;&lt;i&gt;Environ Toxicol Chem&lt;/i&gt;&lt;span&gt;&amp;nbsp;2016;9999:1&amp;ndash;4. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.&lt;/span&gt;&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1002/etc.3490</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>SETAC</dc:publisher>
  <dc:title>An automated approach to Litchfield and Wilcoxon's evaluation of dose–effect experiments using the R package LW1949</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>