<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>Gary A. Wedemeyer</dc:contributor>
  <dc:creator>Paul W. Davis</dc:creator>
  <dc:date>1971</dc:date>
  <dc:description>&lt;p&gt;1. The Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;-activated, Mg&lt;sup&gt;2+&lt;/sup&gt;-dependent-ATPase enzyme system in a heavy microsomal fraction of rainbow trout (&lt;i&gt;Salmo gairdneri&lt;/i&gt;) brain was inhibited &lt;i&gt;in vitro&lt;/i&gt; by chlorinated hydrocarbon pesticides.&lt;br&gt;&lt;/p&gt;&lt;p id=""&gt;2. T&lt;sub&gt;50&lt;/sub&gt; (concentration at 50 per cent inhibition) values for dicofol, endosulfan and DDT were &lt;span id="mmlsi1" class="mathmlsrc"&gt;&lt;span class="formulatext stixSupport mathImg" title="Click to view the MathML source" data-mathurl="/science?_ob=MathURL&amp;amp;_method=retrieve&amp;amp;_eid=1-s2.0-030504917190157X&amp;amp;_mathId=si1.gif&amp;amp;_user=111111111&amp;amp;_pii=030504917190157X&amp;amp;_rdoc=1&amp;amp;_issn=03050491&amp;amp;md5=dcbdcbdbc62c4523aa679a14b036517c"&gt;5 × 10&lt;sup&gt;−6&lt;/sup&gt;&lt;/span&gt;&lt;/span&gt;, &lt;span id="mmlsi2" class="mathmlsrc"&gt;&lt;span class="formulatext stixSupport mathImg" title="Click to view the MathML source" data-mathurl="/science?_ob=MathURL&amp;amp;_method=retrieve&amp;amp;_eid=1-s2.0-030504917190157X&amp;amp;_mathId=si2.gif&amp;amp;_user=111111111&amp;amp;_pii=030504917190157X&amp;amp;_rdoc=1&amp;amp;_issn=03050491&amp;amp;md5=d4f60238a2f598a9c93dc765c440149c"&gt;3 × 10&lt;sup&gt;−5&lt;/sup&gt;&lt;/span&gt;&lt;/span&gt; and &lt;span id="mmlsi3" class="mathmlsrc"&gt;&lt;span class="formulatext stixSupport mathImg" title="Click to view the MathML source" data-mathurl="/science?_ob=MathURL&amp;amp;_method=retrieve&amp;amp;_eid=1-s2.0-030504917190157X&amp;amp;_mathId=si3.gif&amp;amp;_user=111111111&amp;amp;_pii=030504917190157X&amp;amp;_rdoc=1&amp;amp;_issn=03050491&amp;amp;md5=1ec85792d6e93012cfc39b9f5dbee745"&gt;1 × 10&lt;sup&gt;−4&lt;/sup&gt;&lt;/span&gt;&lt;/span&gt; M respectively. Similar inhibition by these pesticides occurred in kidney and gill ATPase preparations.&lt;/p&gt;&lt;p id=""&gt;3. An unexpected finding was a failure of the classic inhibitor, ouabain, to block the Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;-activated component of ATPase activity in the gill.&lt;/p&gt;&lt;p id=""&gt;4. It is suggested that inhibition of ATPase activity may be a causal factor in the toxic effects of organochlorine pesticides in fishes.&lt;/p&gt;&lt;p&gt;&lt;/p&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1016/0305-0491(71)90157-X</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Na+, K+-activated-ATPase inhibition in rainbow trout: A site for organochlorine pesticide toxicity?</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>