Margaret Hunter
Maria Paula Cruz-Schneider
Leonardo Sena
Robert K. Bonde
Michael F. Criscitiello
Breanna Breaux
2018
<p><span>The Florida manatee (</span><i>Trichechus manatus latirostris</i><span><span>) has limited diversity in the immunoglobulin heavy chain. We therefore investigated the antigen receptor loci of the other arm of the adaptive immune system: the T cell receptor. M</span><span><span><span><span><span>anatees are the first species from Afrotheria, a basal eutherian superorder, to have an in-depth characterization of all T cell receptor loci. By annotating the genome and expressed transcripts, we found that each chain has distinct features that correlates to their individual functions. The genomic organization also plays a role in modulating sequence conservation between species. There were extensive V subgroup synteny blocks in the TRA and TRB l</span></span></span>oci between<span> </span></span></span></span><i>T. m. latirostris</i><span>and human. Increased genomic locus complexity correlated to increased locus synteny. We also identified evidence for a VHD pseudogene for the first time in a eutherian mammal. These findings emphasize the value of including species within this basal eutherian radiation in comparative studies.</span></p>
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10.1016/j.dci.2018.04.007
en
Elsevier
The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V subgroup synteny and chain-specific evolution
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