Thomas G. Bean Michelle L. Hladik Barnett A. Rattner Kathryn Kuivila Michael S. Gross 2020 Pesticides coated to the seed surface potentially pose an ecological risk to granivorous birds that consume incompletely buried or spilled seeds. To assess the toxicokinetics of seeds treated with current-use fungicides, Japanese quail (Coturnix japonica) were orally dosed with commercially coated wheat seeds. Quail were exposed to metalaxyl, tebuconazole, and fludioxonil at either a low (0.07, 0.03, and 0.03 mg/kg body weight) or high dose (0.2, 0.09, and 0.1 mg/kg body weight). Fungicides were rapidly absorbed and distributed to tissues. Tebuconazole was metabolized into t-butylhydroxy-tebuconazole. All compounds were eliminated to below detection limits within 24 h. The high detection frequencies observed in fecal samples potentially offers a noninvasive matrix to monitor pesticide exposure. Summing total body burden across plasma, tissue, and fecal samples, less than 9% of the administered dose was identified as the parent fungicide, demonstrating the importance to monitor both active ingredients and their metabolites in biological samples. application/pdf 10.1021/acs.jafc.9b05668 en ACS Uptake, metabolism, and elimination of fungicides from coated wheat seeds in Japanese quail (Coturnix japonica) article