<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:contributor>Anna Frick</dc:contributor>
  <dc:contributor>Catherine Pongratz</dc:contributor>
  <dc:contributor>Kimberly Spink</dc:contributor>
  <dc:contributor>Catherine Xavier</dc:contributor>
  <dc:contributor>Jonas Bonnedahl</dc:contributor>
  <dc:contributor>Andrew M. Ramey</dc:contributor>
  <dc:creator>Christina Ahlstrom</dc:creator>
  <dc:date>2021</dc:date>
  <dc:description>&lt;div id="abst0010"&gt;&lt;h3 id="sect0015" class="u-h4 u-margin-m-top u-margin-xs-bottom"&gt;Objectives&lt;/h3&gt;&lt;p id="spar0025"&gt;Wildlife may harbor clinically important antimicrobial resistant (AMR) bacteria, but the role of wildlife in the epidemiology of AMR bacterial infections in humans is largely unknown. In this study, we aimed to assess dissemination of the&lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;KPC&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;carbapenemase gene among humans and gulls in Alaska.&lt;/p&gt;&lt;/div&gt;&lt;div id="abst0015"&gt;&lt;h3 id="sect0020" class="u-h4 u-margin-m-top u-margin-xs-bottom"&gt;Methods&lt;/h3&gt;&lt;p id="spar0030"&gt;We performed whole genome sequencing to determine the genetic context of&lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;KPC&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;in bacterial isolates from all four human carbapenemase-producing Enterobacteriaceae (CPE) infections reported in Alaska between 2013–2018 and to compare sequences to seven previously reported CPE isolates from gull feces within the same region and time period.&lt;/p&gt;&lt;/div&gt;&lt;div id="abst0020"&gt;&lt;h3 id="sect0025" class="u-h4 u-margin-m-top u-margin-xs-bottom"&gt;Results&lt;/h3&gt;&lt;p id="spar0035"&gt;Genomic analysis of CPE isolates suggested independent acquisition events among humans with no evidence for direct transmission of&lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;KPC&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;between people and gulls. However, some isolates shared conserved genetic elements surrounding&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;KPC&lt;/sub&gt;, suggesting possible exchange between species.&lt;/p&gt;&lt;/div&gt;&lt;div id="abst0025"&gt;&lt;h3 id="sect0030" class="u-h4 u-margin-m-top u-margin-xs-bottom"&gt;Conclusions&lt;/h3&gt;&lt;p id="spar0040"&gt;Our results highlight the genomic plasticity associated with&lt;i&gt;bla&lt;/i&gt;&lt;sub&gt;KPC&lt;/sub&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;and demonstrate that sampling of wildlife may be useful for identifying clinically relevant antimicrobial resistance not observed through local passive surveillance in humans.&lt;/p&gt;&lt;/div&gt;</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>10.1016/j.jgar.2021.02.028</dc:identifier>
  <dc:language>en</dc:language>
  <dc:publisher>Elsevier</dc:publisher>
  <dc:title>Genomic comparison of carbapenem-resistant Enterobacteriaceae from humans and gulls in Alaska</dc:title>
  <dc:type>article</dc:type>
</oai_dc:dc>