Robert S. Cornman 2023 <p>Apis mellifera filamentous virus (AmFV) is a large double-stranded DNA virus of uncertain phylogenetic position that infects honey bees (<i>Apis mellifera</i>). Little is known about AmFV evolution or molecular aspects of infection. Accurate annotation of open-reading frames (ORFs) is challenged by weak homology to other known viruses. This study was undertaken to evaluate ORFs (including coding-frame conservation, codon bias, and purifying selection), quantify genetic variation within AmFV, identify host characteristics that covary with infection rate, and examine viral expression patterns in different tissues.</p> application/pdf 10.7717/peerj.16455 en PeerJ Data mining reveals tissue-specific expression and host lineage-associated forms of Apis mellifera filamentous virus article