A. Wunschmann Kimberlee B. Beckmen L. B. Broughton-Neiswanger E. L. Buckles J. Hugh Ellis S. D. Fitzgerald Robert Gerlach S. Hawkins Hon S. Ip Julia S. Lankton E. M. Lemley J. B. Lenoch M. L. Killian K. Lantz L. Long R. Maes M. Mainenti J. Melotti M. E. Moriarty S. Nakagun R. M. Ruden Valerie I. Shearn-Bochsler D.A. Thompson M. K. Torchetti A. J. Van Wettere A. G. Wise A. L. Lim E. J. Elsmo 2023 <div id="abstract" class="card"><div class="card-body bg-tertiary"><p>We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affected mammals include 50 red foxes (<i>Vulpes vulpes</i>), 6 striped skunks (<i>Mephitis mephitis</i>), 4 raccoons (<i>Procyon lotor</i>), 2 bobcats (<i>Lynx rufus</i>), 2 Virginia opossums (<i>Didelphis virginiana</i>), 1 coyote (<i>Canis latrans</i>), 1 fisher (<i>Pekania pennanti</i>), and 1 gray fox (<i>Urocyon cinereoargenteus</i>). Infected mammals showed primarily neurologic signs. Necrotizing meningoencephalitis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.</p></div></div> application/pdf 10.3201/eid2912.230464 en Centers for Disease Control and Prevention Highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b infections in wild terrestrial mammals, United States, 2022 article