The antibiotic actidione was found to be highly repellent to laboratory rats and to significantly reduce gnawing attacks upon treated paperboards. Rats refused to accept food or water containing this material even under conditions of acute starvation and died of starvation and thirst rather than accept water containing 1.0 mg. of actidione per liter. The compound is highly toxic to rats with the minimum lethal dose by oral administration being approximately 1.0 mg./Kg. body weight. Paperboard treated with the compound resisted gnawing attacks by specially trained and motivated rats for periods of two hundred hours, although similar untreated boards were pierced within thirty to sixty minutes.
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Pathologic changes in both acute and chronic poisoning were studied. Data are presented showing that diagnosis can be made accurately by chemical analysis of stored tissues in cases of phosphorus poisoning.","language":"English","publisher":"Elsevier","doi":"10.1002/jps.3030390308","usgsCitation":"Coburn, D.R., DeWitt, J., Derby, J., and Ediger, E., 1950, Phosphorus poisoning in waterfowl: Journal of the American Pharmaceutical Association, Scientific Edition, v. 39, no. 3, p. 151-158, https://doi.org/10.1002/jps.3030390308.","productDescription":"8 p.","startPage":"151","endPage":"158","numberOfPages":"8","costCenters":[{"id":531,"text":"Patuxent Wildlife Research Center","active":true,"usgs":true}],"links":[{"id":197722,"rank":1,"type":{"id":24,"text":"Thumbnail"},"url":"https://pubs.usgs.gov/thumbnails/outside_thumb.jpg"}],"volume":"39","issue":"3","noUsgsAuthors":false,"publicationStatus":"PW","scienceBaseUri":"4f4e4adbe4b07f02db685f66","contributors":{"authors":[{"text":"Coburn, D. 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Of the five previously described species assigned to this genus from this area, four are reduced to subspecific rank under the European genotype, A croricnus stylator (Thunberg). Three subspecies and one species are described as new, and typical stylator is recorded from America for the first time.
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