Table 3. Results of quality control analyses for pharmaceutical chemicals included in this study.
[The 2002 spike recovery data were from laboratory data collected throughout fiscal year 2002 — before, during, and after this study. %, percent;
Std. Dev., standard deviation of spike recovery results; μg/L, microgram per liter]
| Compound |
Clean blanks? |
Range of spike recovery (this study, %) |
Mean (and Std. Dev.) of 67 set spikes (2002 results, %) |
Comment |
| Acetaminophen |
yes |
69–88 |
72 (15) |
Results reported without qualification. |
| Albuterol (Salbutamol) |
yes |
70–90 |
74 (10) |
Results reported without qualification. |
| Caffeine |
yes |
75–104 |
85 (16) |
Results reported without qualification. |
| Carbamazepine |
yes |
68–84 |
71 (11) |
Results reported without qualification. |
| Cimetidine |
yes |
33–43 |
30 (9.3) |
Reduced probability of low-level detection. Reported concentrations are estimates. |
| Codeine |
yes |
66–91 |
94 (25) |
Results reported without qualification. |
| Cotinine |
yes |
68–92 |
74 (12) |
Results reported without qualification. |
| Dehydronifedipine |
yes |
71–100 |
77 (15) |
Results reported without qualification. |
| Diltiazem |
yes |
48–61 |
47 (11) |
Reported concentrations are estimates. |
| 1,7-Dimethylxanthine |
yes |
96–127 |
105 (36) |
Results reported without qualification. |
| Diphenhydramine |
yes |
51–62 |
53 (11) |
Reported concentrations are estimates. |
| Fluoxetine |
no |
19–43 |
27 (14) |
Blank problems (up to 0.004 μg/L). Reduced probability of low-level detection. Reported concentrations are estimates. |
| Gemfibrozil |
yes |
59–87 |
30 (21) |
Reported concentrations are estimates. |
| Ibuprofen |
yes |
24–121 |
51 (24) |
Variable spike recovery. Imprecise quantitation. Reported concentrations are estimates. |
| Metformin |
yes |
0–2 |
4 (4.8) |
Very low probability of low-level detection. No concentrations reported, only detections. |
| Miconazole |
yes |
1–22 |
6 (7.1) |
Very low probability of low-level detection. No concentrations reported, only detections. |
| Ranitidine |
yes |
45–56 |
41 (13) |
Reported concentrations are estimates. |
| Sulfamethoxazole |
yes |
64–90 |
51 (18) |
Reported concentrations are estimates. |
| Thiabendazole |
yes |
73–94 |
75 (16) |
Results reported without qualification. |
| Trimethoprim |
yes |
67–88 |
70 (12) |
Results reported without qualification. |
| Warfarin |
yes |
59–80 |
63 (13) |
Results reported without qualification. |
|
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U.S. Department of the Interior | U.S. Geological Survey
