Molecular characteristics versus biological activity

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The molecular characteristics of mononitrophenols containing halogens not only play a key role in their biological activity but provide a novel example of selective toxicity among vertebrate animals. It has been reported that efforts to control the parasitic sea lamprey in the Great Lakes are directed at present to the applications of a selective toxicant to streams inhabited by lamprey larvae. Since 1961, the larvicide that has been used almost exclusively in the control program has been 3-trifluoromethyl-4-nitrophenol (TFM). However, this is only one of about 15 closely related compounds, all halogen-containing mononitrophenols, that display a selectively toxic action upon lampreys. Although not all of the halogenated mononitrophenols are selectively toxic to lampreys (in fact, fewer than half of those tested), no other group of related compounds has displayed any useful larvicidal activity except for the substituted nitrosalicylanilides.
Publication type Article
Publication Subtype Journal Article
Title Molecular characteristics versus biological activity
Series title Chemistry
Volume 40
Issue 9
Year Published 1967
Language English
Contributing office(s) Great Lakes Science Center
Description p. 28-30
Larger Work Type Article
Larger Work Subtype Journal Article
Larger Work Title Chemistry
First page 28
Last page 30
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