Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri
Journal of the Fisheries Research Board of Canada
By: J. B. Hunn, R.A. Schoettger, and W. A. Willford
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Abstract
Rainbow trout (Salmo gairdneri) anesthetized in 100 mg/liter of M.S. 222 at 12 C excreted the drug in free and acetylated forms via the urine during a 24-hr recovery period in freshwater. Of the M.S. 222 excreted, 77-96% was acetylated. Blood levels of free drug in anesthetized trout approximated 75% of the anesthetic concentration, but the amount of acetylated M.S. 222 was relatively insignificant. The blood and urine were cleared of the two fractions of M.S. 222 in 8 and 24 hr respectively. Low levels of aromatic amines of natural origin occurred in blood and urine and were subtracted from measurements of M.S. 222. Intraperitoneal injections of 10-100 mg/kg of M.S. 222 did not induce anesthesia; however, the 24-hr pattern of drug excretion was similar to that observed after anesthesia by immersion. Only 15-21 % of the injected dose was found in the urine, suggesting a second route of drug elimination.
Suggested Citation
Hunn, J., Schoettger, R., Willford, W., 1968, Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri: Journal of the Fisheries Research Board of Canada, v. 25, no. 1, p. 25-31, https://doi.org/10.1139/f68-003.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Turnover and urinary excretion of free and acetylated MS-222 rainbow trout, Salmo gairdneri |
| Series title | Journal of the Fisheries Research Board of Canada |
| DOI | 10.1139/f68-003 |
| Volume | 25 |
| Issue | 1 |
| Year Published | 1968 |
| Language | English |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | pp. 25-31 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Journal of the Fisheries Research Board of Canada |
| First page | 25 |
| Last page | 31 |