Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss
Xenobiotica
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Abstract
1. Branchial and urinary elimination of benzocaine residues was evaluated in adult rainbow trout, oncorhynchus mykiss, given a single dorsal aortic dose of c-14-benzocaine hydrochloride.^2. Branchial elimination of benzocaine residues was rapid and accounted for 59.2% Of the dose during the first 3 h after dosing. Renal elimination of radioactivity was considerably slower; the kidney excreted 2.7% Dose within 3 h and 9.0% Within 24 h. Gallbladder bile contained 2.0% Dose 24 h after injection.^3. Of the radioactivity in radiochromatograms from water taken 3 min after injection, 87.3% Was benzocaine and 12.7% Was n-acetylated benzocaine. After 60 min, 32.7% Was benzocaine and 67.3% Was n-acetylated benzocaine.^4. Of the radioactivity in radiochromatograms from urine taken 1 h after dosing, 7.6% Was para-aminobenzoic acid, 59.7% Was n-acetylated para-aminobenzoic acid, 19.5% Was benzocaine, and 8.0% Was n-acetylated benzocaine. The proportion of the radioactivity in urine changed with time so that by 20 h, 1.0% Was para-aminobenzoic acid and 96.6% Was n-acetylated para-aminobenzoic acid.^5. Benzocaine and a more hydrophobic metabolite, n-acetylated benzocaine, were eliminated primarily through the gills; renal and biliary pathways were less significant elimination routes for benzocaine residues.
Suggested Citation
Meinertz, J., Gingerich, W., and Allen, J.L., 1991, Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss: Xenobiotica, v. 21, no. 4, p. 525-533, https://doi.org/10.3109/00498259109039492.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss |
| Series title | Xenobiotica |
| DOI | 10.3109/00498259109039492 |
| Volume | 21 |
| Issue | 4 |
| Publication Date | August 27, 2009 |
| Year Published | 1991 |
| Language | English |
| Publisher | University of Wisconsin; U.S. Fish and Wildlife Service |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | pp. 525-533 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Xenobiotica |
| First page | 525 |
| Last page | 533 |