Protection of black-tailed prairie dogs (Cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine
Infection and Immunity
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Abstract
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Protection of black-tailed prairie dogs (Cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine |
| Series title | Infection and Immunity |
| DOI | 10.1128/IAI.72.9.5502-5505.2004 |
| Volume | 72 |
| Issue | 9 |
| Year Published | 2004 |
| Language | English |
| Publisher | American Society for Microbiology |
| Contributing office(s) | National Wildlife Health Center |
| Description | 4 p. |
| First page | 5502 |
| Last page | 5505 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |