Recombinant F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against virulent Yersinia pestis infection
Journal of Zoo and Wildlife Medicine
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Abstract
Black-footed ferrets (Mustela nigripes) are highly susceptible to sylvatic plague, caused by the bacterium Yersinia pestis, and this disease has severely hampered efforts to restore ferrets to their historic range. A study was conducted to assess the efficacy of vaccination of black-footed ferrets against plague using a recombinant protein vaccine, designated F1-V, developed by personnel at the U.S. Army Medical Research Institute of Infectious Diseases. Seven postreproductive black-footed ferrets were immunized with the vaccine, followed by two booster immunizations on days 23 and 154; three control black-footed ferrets received a placebo. After the second immunization, antibody titers to both F1 and V antigen were found to be significantly higher in vaccinates than controls. On challenge with 7,800 colony-forming units of virulent plague by s.c. injection, the three control animals died within 3 days, but six of seven vaccinates survived with no ill effects. The seventh vaccinate died on day 8. These results indicate that black-footed ferrets can be immunized against plague induced by the s.c. route, similar to fleabite injection.
Suggested Citation
Rocke, T.E., Mencher, J., Smith, S., Friedlander, A.M., Andrews, G., Baeten, L., 2004, Recombinant F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against virulent Yersinia pestis infection: Journal of Zoo and Wildlife Medicine, v. 35, no. 2, p. 142-146, https://doi.org/10.1638/03-021.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Recombinant F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against virulent Yersinia pestis infection |
| Series title | Journal of Zoo and Wildlife Medicine |
| DOI | 10.1638/03-021 |
| Volume | 35 |
| Issue | 2 |
| Year Published | 2004 |
| Language | English |
| Publisher | American Association of Zoo Veterinarians |
| Contributing office(s) | National Wildlife Health Center |
| Description | 5 p. |
| First page | 142 |
| Last page | 146 |