Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (iOncorhynchus mykiss)
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Abstract
The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0·2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0·01, 0·05 and 0·2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0·01, 0·05 and 0·2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater adaptation of salmonids.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss) |
| Series title | Journal of Endocrinology |
| DOI | 10.1677/joe.0.1300087 |
| Volume | 130 |
| Year Published | 1991 |
| Language | English |
| Publisher | Society for Endocrinology |
| Contributing office(s) | Leetown Science Center |
| Description | 6 p. |
| First page | 87 |
| Last page | 92 |
| Google Analytic Metrics | Metrics page |