Toxicity and repellency to rats of actidione
Journal of the American Pharmaceutical Association, Scientific Edition
By: R. Traub, J.B. DeWitt, J.F. Welch, and D. Newman
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Abstract
The antibiotic actidione was found to be highly repellent to laboratory rats and to significantly reduce gnawing attacks upon treated paperboards. Rats refused to accept food or water containing this material even under conditions of acute starvation and died of starvation and thirst rather than accept water containing 1.0 mg. of actidione per liter. The compound is highly toxic to rats with the minimum lethal dose by oral administration being approximately 1.0 mg./Kg. body weight. Paperboard treated with the compound resisted gnawing attacks by specially trained and motivated rats for periods of two hundred hours, although similar untreated boards were pierced within thirty to sixty minutes.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Toxicity and repellency to rats of actidione |
| Series title | Journal of the American Pharmaceutical Association, Scientific Edition |
| DOI | 10.1002/jps.3030391006 |
| Volume | 39 |
| Issue | 10 |
| Year Published | 1950 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 4 p. |
| First page | 552 |
| Last page | 555 |