Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice
Toxicology Letters
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Abstract
Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days substantially inhibited brain AChE activity, but did not affect plasma LH concentration. These preliminary findings suggest that acute exposure to organophosphorus insecticides may affect LH secretion and possibly reproductive function.
Suggested Citation
Rattner, B., and Michael, S., 1985, Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice: Toxicology Letters, v. 24, no. 1, p. 65-69.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Organophosphorus insecticide induced decrease in plasma luteinizing hormone concentration in white-footed mice |
| Series title | Toxicology Letters |
| Volume | 24 |
| Issue | 1 |
| Year Published | 1985 |
| Language | English |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 65-69 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Toxicology Letters |
| First page | 65 |
| Last page | 69 |