Divergent effects of postmortem ambient temperature on organophosphorus- and carbamate-inhibited brain cholinesterase activity in birds
Pesticide Biochemistry and Physiology
By: E. F. Hill
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Abstract
Time- and temperature-dependent postmortem changes in inhibited brain cholinesterase (ChE) activity may confound diagnosis of field poisoning of wildlife by anticholinesterase pesticide. Carbamate-inhibited ChE activity may return to normal within 1 to 2 days of exposure of intact carcass to moderate ambient temperature (18-32C). Organophosphorus-inhibited ChE activity becomes more depressed over the same time. Uninhibited ChE activity was resilient to above freezing temperature to 32C for 1 day and 25C for 3 days. Carbamate- and organophosphorus-inhibited ChE can be separated by incubation of homogenate for 1 hour at physiological temperatures; carbamylated ChE can be readily reactivated while phosphorylated ChE cannot.
Suggested Citation
Hill, E.F., 1989, Divergent effects of postmortem ambient temperature on organophosphorus- and carbamate-inhibited brain cholinesterase activity in birds: Pesticide Biochemistry and Physiology, v. 33, no. 3, p. 264-275, https://doi.org/10.1016/0048-3575(89)90125-9.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Divergent effects of postmortem ambient temperature on organophosphorus- and carbamate-inhibited brain cholinesterase activity in birds |
| Series title | Pesticide Biochemistry and Physiology |
| DOI | 10.1016/0048-3575(89)90125-9 |
| Volume | 33 |
| Issue | 3 |
| Year Published | 1989 |
| Language | English |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 264-275 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Pesticide Biochemistry and Physiology |
| First page | 264 |
| Last page | 275 |