Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings
Journal of Toxicology and Environmental Health
By: D. J. Hoffman, G. H. Heinz, and A. J. Krynitsky
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Abstract
Selenium from selenomethionine accumulated in a dose-dependent manner in the liver, resulting in a decrease in hepatic-reduced glutathione with a corresponding decrease in total hepatic thiols. There was a dose-dependent increase in the oxidized to reduced glutathione ratio, and an increase in lipid peroxidation. These findings indicate that Se in the diet at 10 ppm and higher causes significant sublethal alterations in mallard ducklings, and 20-40 ppm causes significant hepatotoxicity.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings |
| Series title | Journal of Toxicology and Environmental Health |
| DOI | 10.1080/15287398909531296 |
| Volume | 27 |
| Issue | 2 |
| Year Published | 1989 |
| Language | English |
| Publisher | Taylor and Francis |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 263-271 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Journal of Toxicology and Environmental Health |
| First page | 263 |
| Last page | 271 |