Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds
Life Sciences
By: H.P. Pan, J.R. Fouts, and T.R. Devereux
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Abstract
Hepatic microsomes prepared from red-winged blackbirds and albino rats were incubated with N,N-dimethylaniline (DMA)_in complete incubation mixtures at pH 7.9 and 37?C for 10 min. Formaldehyde and N,N-dimethylaniline--oxide produced from DMA were measured. Redwings were found to have significantly lower N-demethylation activities than rats, and redwings had only marginal or no N-oxidation activities. Hepatic microsomes from redwings did not further metabolize the N-oxide. The N-oxidation and N-demethylation activities of brown-headed cowbirds, common grackles, and starlings were similar to those of redwings.
Suggested Citation
Pan, H., Fouts, J., Devereux, T., 1975, Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds: Life Sciences, v. 17, no. 5, p. 819-825, https://doi.org/10.1016/0024-3205(75)90540-8.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Hepatic microsomal N-oxidation and N-demethylation of N,N-dimethylaniline in red-winged blackbird compared with rat and other birds |
| Series title | Life Sciences |
| DOI | 10.1016/0024-3205(75)90540-8 |
| Volume | 17 |
| Issue | 5 |
| Year Published | 1975 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 7 p. |
| First page | 819 |
| Last page | 825 |