Percutaneous absorption of several chemicals, some pesticides included, in the red-winged blackbird
Environmental Physiology and Biochemistry
7119_Rogers.pdf
By: J.G. Rogers Jr., R.H. Cagan, and M.R. Kare
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Abstract
Percutaneous absorption in vivo through the skin of the feet of the red-winged blackbird (Agelaius phoeniceus) has been investigated. Absorption after 18-24 hours exposure to 0.01 M solutions of salicylic acid, caffeine, urea, 2,4-D, dieldrin, diethylstilbesterol, and DDT was measured. Of these, only DDT and diethylstilbesterol were not absorbed to a measurable degree. The solvents ethanol, dimethylsulfoxide (DMSO), and vegetable oil were compared with water in their effects on the absorption ofcaffeine, urea, and salicylic acid. Ethanol, DMSO,and oil each decreased percutaneous absorption of salicylic acid. DMSO increased absorption of caffeine, and ethanol had no effect on it. Neither DMSO nor ethanol affected penetration of urea. Partition coefficients (K) (epidermis/water) were determined for all seven penetrants. Compounds with higher values of K showed lower percutaneous absorption. These findings suggest that K may be useful to predict percutaneous absorption in vivo. It appears unlikely that percutaneous absorption contributes greatly to the body burden of 2,4-D and dieldrin in A. phoeniceus.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Percutaneous absorption of several chemicals, some pesticides included, in the red-winged blackbird |
| Series title | Environmental Physiology and Biochemistry |
| Volume | 4 |
| Issue | 3 |
| Year Published | 1974 |
| Language | English |
| Contributing office(s) | Patuxent Wildlife Research Center |
| Description | 104-111 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Environmental Physiology and Biochemistry |
| First page | 104 |
| Last page | 111 |
| Google Analytic Metrics | Metrics page |