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Abstract
Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 (mu or u)g/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 (mu or u)g/L and for ET was 248 (mu or u)g/L.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system |
| Series title | Bulletin of Environmental Contamination and Toxicology |
| Volume | 85 |
| Issue | 5 |
| Year Published | 2010 |
| Language | English |
| Publisher | Springer |
| Publisher location | Netherlands |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | 5 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Bulletin of Environmental Contamination and Toxicology |
| First page | 447 |
| Last page | 451 |
| Country | United States |
| Google Analytic Metrics | Metrics page |