Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.
Toxicon
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By: L.S. Siegel and J.I. Price
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Abstract
Clostridium botulinum neurotoxins inhibit acetylcholine release at neuromuscular junctions. Agents stimulating neurotransmitter efflux, such as 3,4-diaminopyridine (3,4-DAP), could be useful for botulism therapy. Treatment with 3,4-DAP (8 mg/kg hourly, beginning 3 hr after toxin injection) failed to increase the survival times of mice receiving 10, 20 or 40 LD50 type C, but did prolong the survival of those receiving 20 LD50 type A. This difference in 3,4-DAP efficacy may reflect variations in the molecular mechanism of action of types A and C botulinum neurotoxins.
Suggested Citation
Siegel, L., and Price, J., 1987, Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism.: Toxicon, v. 25, no. 9, p. 1015-1018, https://doi.org/10.1016/0041-0101(87)90166-8.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Ineffectiveness of 3,4-diaminopyridine as a therapy for type C botulism. |
| Series title | Toxicon |
| DOI | 10.1016/0041-0101(87)90166-8 |
| Volume | 25 |
| Issue | 9 |
| Year Published | 1987 |
| Language | English |
| Contributing office(s) | National Wildlife Health Center |
| Description | 4 p. |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Toxicon |
| First page | 1015 |
| Last page | 1018 |