Uptake, tissue distribution, and metabolism of malachite green in the channel catfish (Ictalurus punctatus)
Canadian Journal of Fisheries and Aquatic Sciences
Abstract has subscript/superscript to be fixed
By: S. M. Plakas, K. R. El Said, G. R. Stehly, W.H. Gingerich, and J. L. Allen
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Abstract
The disposition of malachite green was determined in channel catfish (Ictalurus punctatus) after intravascular dosing (0.8 mg . Kg-1) or waterborne exposure (0.8 mg . L-1 for 1 h). After intravascular dosing, mean plasma concentrations of the parent compound exhibited a triphasic decline with a terminal elimination half-life of 6.2 h. Malachite green was rapidly absorbed and concentrated in the tissues during waterborne exposure. The rate of accumulation was directly related to pH of the exposure water. After waterborne exposure, elimination of the parent compound from plasma also was triphasic with a terminal half-life of 4.7 h. In muscle, the half-life of the parent compound was approximately 67 h. Malachite green and its metabolites were widely distributed in all tissues. In fish exposed to C-14-labeled malachite green, total drug equivalent concentrations were highest in abdominal fat and lowest in plasma. Malachite green was rapidly and extensively metabolized to its reduced form, leucomalachite green, which was slowly eliminated from the tissues. Leucomalachite green is an appropriate target analyte for monitoring exposure of channel catfish to this drug.
Suggested Citation
Plakas, S.M., El Said, K.R., Stehly, G., Gingerich, W., and Allen, J.L., 1996, Uptake, tissue distribution, and metabolism of malachite green in the channel catfish (Ictalurus punctatus): Canadian Journal of Fisheries and Aquatic Sciences, v. 53, no. 6, p. 1427-1433, https://doi.org/10.1139/f96-061.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Uptake, tissue distribution, and metabolism of malachite green in the channel catfish (Ictalurus punctatus) |
| Series title | Canadian Journal of Fisheries and Aquatic Sciences |
| DOI | 10.1139/f96-061 |
| Volume | 53 |
| Issue | 6 |
| Year Published | 1996 |
| Language | English |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | pp. 1427-1433 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Canadian Journal of Fisheries and Aquatic Sciences |
| First page | 1427 |
| Last page | 1433 |