Teleseismic data were recorded within the Sierra Nevada to look for lateral variations in the upper mantle. The data were collected at both temporary and permanent stations, and P wave residuals were computed. After correcting the P residual data for crustal and topographic effects, there is still a variation of as much as 0.5-0.6 s from the north end of the Sierra Nevada to Mono Lake, located east of the central part of the range. In addition, there are significant variations in travel time patterns, depending on the azimuth of wave arrivals. Two simple modeling approaches have been used to infer the upper mantle velocity structure from the observed variations in travel time. In the first, it is assumed that the velocity variations are distributed throughout a depth range of about 60–160 km. One model that fits the data indicates a north-to-south trend in upper mantle P velocities from about 7.9 km/s at the north end of the Sierra to 7.6 km/s near Mono Lake. Superimposed is a west-to-east trend from 7.85 km/s under the Sierra Nevada crest to 7.7 km/s east of Lake Tahoe. In the second modeling approach, a fixed velocity contrast is assumed between the lithosphere and asthenosphere with variations in travel time resulting from variations in lithospheric thickness. One model, consistent with the observations, indicates a thinning of the lithosphere from 110 km at the north end of the Sierra to 60 km near Mono Lake.