The observations of short-term decreases in helium soil-gas concentrations along the San Andreas Fault in central California have been correlated with subsequent earthquake activity. The area of study is elliptical in shape with radii approximately 160??80 km, centered near San Benito, and with the major axis parallel to the Fault. For 83 percent of the M>4 earthquakes in this area a helium decrease preceded seismic activity by 1.5 to 6.5 weeks. There were several earthquakes without a decrease and several decreases without a corresponding earthquake. Owing to complex and unresolved interaction of many geophysical and geochemical parameters, no suitable model is yet developed to explain the observations. ?? 1985 Birkha??user Verlag.