Instrumentation of structures is part of earthquake hazard mitigation program of many institutions, including the United States Geological Survey (USGS). The USGS Strong-Motion Instrumentation of Structures Program is designed to complement other programs and to implement its own, within budget and other constraints. This paper reviews the overall national effort, cites examples of structures implemented and describes progress made to date. A recent example of instrumentation of an eight-story building in Charleston, South Carolina is documented.