Since 2.2 Ma, the Yellowstone Plateau volcanic field has produced ∼6000 km³ of rhyolite tuffs and lavas in >60 separate eruptions, as well as ∼ 100 km³ of tholeiitic basalt from >50 vents peripheral to the silicic focus. Intermediate eruptive products are absent. Large calderas collapsed at 2·0, 1·3, and 0·6 Ma on eruption of ash-flow sheets representing at least 2500, 280, and 1000 km³ of zoned magma. Early postcollapse rhyolites show large shifts in Nd, Sr, Pb, and O isotopic compositions caused by assimilation of roof rocks and hydrothermal brines during collapse and resurgence. Younger intracaldera rhyolite lavas record partial isotopic recovery toward precaldera ration. Thirteen extracaldera rhyolites show none of these effects and have sources independent of the subcaldera magma system. Contributions from the Archaean crust have extreme values and wide ranges of Nd-, Sr-, and Pb-isotope ratios, but Yellowstone rhyolites have moderate values and limited ranges. This requires their deep-crustal sources to have been pervasively hybridized (and the Archaean components diluted) by distributed intrusion of Cenozoic basalt, most of which was probably contemporaneous with the Pliocene and Qualernary volcanism. In hybrid sources yielding magmas parental to the subcaldera rhyolites, half or more of the Nd and Sr may have been contributed by such young basalt. Parents for the extracaldera rhyolites, generated beyond the leading edge of the northeast-propagating focus of basaltic intrusion and deep-crustal mobilization, contained smaller fractions of mantle-derived components.