Rb-Sr mean model ages of  for glauconites from the Cambrian lower Bonneterre Formation in southern and central Missouri (in contrast to mean model ages of  from the middle and upper Bonneterre) are in excellent agreement with a Rb-Sr isochron age of  for glauconites from the Magmont mine (Viburnum Trend) in the southeast Missouri lead district. The lower Bonneterre and Mag-mont mine ages probably reflect isotopic resetting, most likely associated with dolomitization and/or Mississippi Valley-type ore formation in the southeast Missouri lead district. The temporal relation between widespread dolomitization and ore formation in Missouri is unclear, but mounting evidence for two Devonian disturbances permits the following interpretation: (1) a Devonian timing (380-400 Ma) for widespread dolomitization, and (2) a Late Devonian-Early Mississippian timing (360-370 Ma) for ore formation in southeast Missouri. A definitive, genetic connection between southeast Missouri ore formation and peak Ouachita-Appalachian orogenesis during Pennsylvanian time (300 Ma) is lacking. Late Devonian-Early Mississippian fluids associated with the earliest stages of collisional tectonics and metamorphism to the south and southeast may have been important in the formation of southeast Missouri ore deposits. These tectonically driven waters may themselves have been the Mississippi Valley-type ore fluids, entering Missouri by way of the Black Warrior basin and Reelfoot rift and/or the Arkoma basin. Alternatively, the movement of orogenic fluids hundreds of kilometers distant may have initiated and distally influenced the migration of more locally derived Mississippi Valley-type ore fluids. Broad regions of Missouri and adjacent areas immediately south and southeast experienced heating and crustal flexing in the Late Devonian, and consequently, preservation of elevated temperatures in Mississippi Valley-type fluids as they move great lateral distances may not be necessary for ore formation in southeast Missouri.