Numerous chemical reactions within clay sequences have been proposed to produce dissolved material for diagenesis of deeply-buried sands. However, reactions responsible for solubilizing inorganic and organic constituents in clays at intermediate depths, and their importance to sandstone diagenesis, have not been evaluated. Results from this study show that the processes of microbial organic-acid production (via fermentation) in clays and microbial organic-acid consumption (via sulfate reduction) in sands effectively link organic-rich clays to sandstone diagenesis in the Black Creek Formation of South Carolina. Diagenetic processes have resulted in the formation of 10 volume percent calcite cement, 0.1 volume percent authigenic pyrite, and 1.5 volume percent secondary porosity in Black Creek sands. However, the distribution of these diagenetic processes is not uniform, resulting in net destruction of porosity in some parts of the sand and net porosity enhancement in other parts. Mass balance-derived rates of microbial organic-acid production (10 (super -5) mmole carbon 1 (super -1) yr (super -1) ) and microbial CO ₂ production (4 x 10 (super -5) mmole l (super -1) yr (super -1) ) show that microbial processes can account for all organic carbon in the calcite cements (at least 11% of carbonate carbon based on isotope-balance calculations), all observed authigenic pyrite, and all observed secondary porosity. These findings show that microbial processes can serve to link organic-rich clays with sandstone diagenesis at intermediate depths.