The Baikal depression occupies a central position in the system of the basins of the Baikal Rift Zone and corresponds to the nucleus from which the continental lithosphere began to open. For different reasons, the internal structure of the Lake Baikal basin remained unknown for a long time. In this article, we present for the first time a synthesis of the data concerning the structure of the sedimentary section beneath Lake Baikal, which were obtained by complex seismic and structural investigations, conducted mainly from 1989 to 1992. We make a brief description of the most interesting seismic profiles which provide a rough idea of a sedimentary unit structure, present a detailed structural interpretation and show the relationship between active faults in the lake, heat flow anomalies and recent hydrothermalism.