Accumulations of deltaic and littoral sediments on the inner continental shelf of Maine, Gulf of Maine, preserve a record of postglacial sea-level changes and shoreline migrations. The depositional response of coastal environments to a cycle of regression, lowstand, and transgression was examined with seismic-reflection profiles, vibracores, and radiocarbon dates collected from sediments at the mouths of the Kennebec and Penobscot Rivers. Sequence-stratigraphic analysis of these data reveals two distinctly different successions of late Quaternary deposits that represent end members in an evolutionary model for this glaciated coast. Seaward of the Kennebec River, coarse-grained shorelines with foreset beds occur at depths of 20–60 m and outline the lobate margin of the Kennebec River paleodelta, a complex, rock-framed accumulation of glaciomarine and deltaic sediments capped by estuarine and marine deposits. Sand derived from this system today supports large barrier spits and extensive salt marshes. In contrast, the mouth of the Penobscot River is characterized by thick deposits of glaciomarine mud overlain by marine mud of Holocene age, including gas-charged zones that have locally evolved into fields of pockmarks. The distinct lack of sand and gravel seaward of the Penobscot River and its abundance seaward of the Kennebec River probably reflect differences in sediment sources and the physiography of the two watersheds. The contrasting stratigraphic framework of these systems demonstrates the importance of understanding local and regional differences in sediment supply, sea-level change, bedrock structure, and exposure to waves and tides in order to model river-mouth deposition on glaciated coasts.