Reexamination of existing trilobite collections from the Kinderhookian (Lower Mississippian) Chouteau Group of central and northeastern Missouri indicates that two different suites of trilobites are present in these two areas of the state. Moreover, the study of these collections has led to the erection of a new genus and four new species. The new genus, Ameropiltonia, is based on a new species, A. lauradanae. This genus and species is commonly confused with Breviphillipsia sampsoni (Vogdes). Elliptophillipsia rotundus, n. sp., differs from the type species of this genus by possessing a rounded frontal lobe to the glabella. The other new species, Perexigupyge chouteauensis and Richterella hessleri, are present in the Compton Limestone of Marion and Ralls counties of northeastern Missouri. Variations in trilobite species found in the Compton Limestone of central Missouri and the northeastern part of the state are interpreted to be environmentally related. It appears that the lime mudstone and wackestone lithologies characteristic of the Compton Limestone of central Missouri were deposited in a low-energy, subtidal shelf setting. The lime packstone-grainstone strata of northeastern Missouri are interpreted to have formed as a tidal sand belt on the eastern margin of the Burlington shelf.