The Late-Glacial and Holocene sedimentary history of the Hauts-Monts area (western Lake Geneva, Switzerland) is reconstructed combining high resolution seismic stratigraphy and well-dated sedimentary cores. Six reflections and seismic units are defined and represented by individual isopach maps, which are further combined to obtain a three-dimensional age-depth model. Slumps, blank areas and various geometries are identified using these seismic data. The sediment depositional areas have substantially changed throughout the lake during the end of the Late-Glacial and the Holocene. These changes are interpreted as the result of variations in the intensity of deep lake currents and the frequency of strong winds determining the distribution of sediment input from the Versoix River and from reworking of previously deposited sediments within the lacustrine basin. The identified changes in sediment distribution allowed us to reconstruct the lake's deep-current history and the evolution of dominant strong wind regimes from the Preboreal to present times.