Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted arctic charr
Environmental Toxicology and Chemistry
By: A.G. Maule, E.H. Jorgensen, M.M. Vijayan, and J.-E.A. Killie
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Abstract
To examine the immunological impacts of polychlorinated biphenyls (PCBs) in an environmentally relevant way, we orally contaminated Arctic charr (Salvelinus alpinus) with Aroclor 1254. After contamination, fish were either fed (0 and 100 mg Aroclor 1254 kg-1 fish wt) or fasted (0, 1, 10, and 100 mg kg-1) to mimic cycles of feeding-fasting experienced by Arctic animals. After four months, PCB concentrations in muscle were the same in fasted and fed fish; however, PCBs in kidneys of fed fish were 33 to 50% of those in fasted fish. Arctic charr were exposed to Aeromonas salmonicida, the bacteria responsible for furunculosis, by cohabitation with infected conspecifics. Fasted fish had a significant trend toward lower survival with higher dose of PCBs - from 68% in controls to 48% in treatment involving 100 mg kg-1. Independent of PCB contamination, fed fish had the lowest survival; we attribute this to stress associated with establishing and maintaining feeding hierarchies. A significant decrease in the activity of lysozyme was observed in skin mucus, as was hemagglutination ability of a putative rhamnose lectin in fasted, but not in fed, PCB-treated fish. These results demonstrate the immunosuppressive effects of PCBs on Arctic charr, and they illustrate the importance of considering environmentally relevant nutritional status in ecotoxicological studies.
Suggested Citation
Maule, A., Jorgensen, E., Vijayan, M., and Killie, J., 2005, Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted arctic charr: Environmental Toxicology and Chemistry, v. 24, no. 1, p. 117-124, https://doi.org/10.1897/03-700.1.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted arctic charr |
| Series title | Environmental Toxicology and Chemistry |
| DOI | 10.1897/03-700.1 |
| Volume | 24 |
| Issue | 1 |
| Publication Date | January 01, 2005 |
| Year Published | 2005 |
| Language | English |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Environmental Toxicology and Chemistry |
| First page | 117 |
| Last page | 124 |