Both msa genes in Renibacterium salmoninarum are needed for full virulence in bacterial kidney disease
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Abstract
Renibacterium salmoninarum, a gram-positive diplococcobacillus that causes bacterial kidney disease among salmon and trout, has two chromosomal loci encoding the major soluble antigen (msa) gene. Because the MSA protein is widely suspected to be an important virulence factor, we used insertion-duplication mutagenesis to generate disruptions of either the msa1 or msa2 gene. Surprisingly, expression of MSA protein in broth cultures appeared unaffected. However, the virulence of either mutant in juvenile Chinook salmon (Oncorhynchus tshawytscha) by intraperitoneal challenge was severely attenuated, suggesting that disruption of the msa1 or msa2 gene affected in vivo expression. Copyright ?? 2006, American Society for Microbiology. All Rights Reserved.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Both msa genes in Renibacterium salmoninarum are needed for full virulence in bacterial kidney disease |
| Series title | Applied and Environmental Microbiology |
| DOI | 10.1128/AEM.72.4.2672-2678.2006 |
| Volume | 72 |
| Issue | 4 |
| Year Published | 2006 |
| Language | English |
| Publisher | American Society for Microbiology |
| Contributing office(s) | Western Fisheries Research Center |
| Description | 7 p. |
| First page | 2672 |
| Last page | 2678 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |
| Google Analytic Metrics | Metrics page |